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These participants achieved a 16.0% weight loss over 68 weeks nearly triple the 5.7% weight loss seen in those who only received behavioral therapy and placebo

140 Conversely, poor sleep can change the composition of the gut microbiome, which may contribute to metabolic disturbance and immune, neurologic, and hormonal dysregulation

Other essential research goals include defining the exact mechanisms of action, unequivocally associating specific probiotic strains with defined health benefits, and establishing the minimum effective concentrations required to produce these therapeutic effects (562)

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